PRIME Centre Wales - Research Publications 


National Institute of Health Research (2016) Dissemination centre themed review Care at the Scene: Research for ambulance services. Available from:

Parental decisions about children's oral health behaviour: relative or absolute? Trubey, Rob J., Moore, Simon C. and Chestnutt, Ivor G. Community Dent Oral Epidemiol. Vol. 45, No. 1
Feb 2017 Pages 35–42. doi: 10.1111/cdoe.12256. 

The Management of Acne Vulgaris in Primary Care: A cohort study of consulting and prescribing patterns using CPRD. Francis NA, Entwistle K, Santer M, Layton AM, Eady EA, Butler CC. Br J Dermatol, 176: 107–115. doi:10.1111/bjd.15081

Improving skin care through data: a pitch for patient safety incident reporting. Samuriwo R, Williams H, Cooper J, Carson-Stevens A. J Wound Care. 2016 Dec 2;25(12):691. DOI: 10.12968/jowc.2016.25.12.691

Matching and accepting assistive technology in multiple sclerosis: A focus group study with people with multiple sclerosis, carers and occupational therapists. Squires LA, Williams N, Morrison VL.  J Health Psychol. 2016 Nov 15. pii: 1359105316677293. [Epub ahead of print]

'On a learning curve for shared decision making: interviews with clinicians using the knee osteoarthritis Option GridTM'. Elwyn G, Rasmussen J, Kinsey K, Firth J, Marrin K, Wood F. J Eval Clin Pract. 2016 Nov 16. doi: 10.1111/jep.12665. [Epub ahead of print]

PTU-148 Endoscopic Surveillance in Dysplastic Barrett’s Oesophagus (BO). HN Alastal, K Nemeth, M Rashid, J Kenkre, A Rasheed. Gut 06/2016; 65(Suppl 1). DOI:10.1136/gutjnl-2016-312388.233

Development of a behaviour change intervention to encourage timely cancer symptom presentation among people living in deprived communities using the Behaviour Change Wheel. Smits S, McCutchan G, Wood F, Edwards A, Lewis I, Robling M, Paranjothy S, Carter B, Townson J, Brain K. Ann Behav Med. (2016). doi:10.1007/s12160-016-9849-x

The Transition to Secondary Progressive Multiple Sclerosis: An Exploratory Qualitative Study of Health Professionals' Experiences. Davies F, Wood F, Brain K, Edwards M, Jones R, Wallbank R, Robertson N, Edwards A. International Journal of MS Care. September/October 2016, Vol. 18, No. 5, pp. 257-264.

Tooth Decorations and Modifications - Current Trends and Clinical Implications. Sangavhi, S and Chestnutt, I.G. Dent Update 2016; 43: 313–318

Motivational interviewing competencies among UK family nurse partnership nurses: a process evaluation component of the building blocks trial. Channon S, Bekkers MJ, Sanders J, Cannings-John R, Robertson L, Bennert K, Butler C, Hood K, Robling M. BMC Nurs. 2016 Sep 20;15:55. doi: 10.1186/s12912-016-0176-0. eCollection 2016.

Examiner reliability in fluorosis scoring: a comparison of photographic and clinical methods.
Mohd Nor NA, Chestnutt IG, Chadwick BL. Community Dent Health. 2016 Jun;33(2):145-50.

Patient Safety Incidents and Adverse Events in Ambulatory Dental Care: A Systematic Scoping Review. Ensaldo-Carrasco E, Suarez-Ortegon MF, Carson-Stevens A, Cresswell K, Bedi R, Sheikh A. J Patient Saf. 2016 Sep 8. [Epub ahead of print]

A review of enhanced paramedic roles during and after hospital handover of stroke, myocardial infarction and trauma patients.
Flynn D, Francis R, Robalino S, Lally J, Snooks H, Rodgers H, McClelland G, Ford G, Price C. BMC Emerg Med. 2016; 17: 5.

Refining Ovarian Cancer Test accuracy Scores (ROCkeTS) - protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer. Sundar S, Rick C, Dowling F, Au P, Snell K, Talapadi NR, Champeneria R, Stobart H, Neal RD, Davenport C, Mallett S, Sutton A, Kehoe S, Timmerman D, Bourne T, Van Calster B, Menon U, Deeks J. BMJ Open 2016;6:e010333. doi: 10.1136/bmjopen-2015-010333

Walking the tightrope: communicating overdiagnosis in modern healthcare. McCaffery K, Jansen J, Scherer L, Thornton H, Hersch J, Carter S, Barratt A, Sheridan S, Moynihan R, Waller J, Brodersen J, Pickles K, Edwards A. BMJ 2016;352:i348 352 doi:

Establishing a set of research priorities in care homes for older people in the UK: a modified Delphi consensus study with care home staff.  Shepherd V, Wood F, Hood K. Age Ageing. (2017) 46 (2): 284-290. DOI: Published: 14 November 2016

An illness-focused interactive booklet to optimise management and medication for childhood fever and infections in out-of-hours primary care: study protocol for a cluster randomised trial. de Bont EGPM, Dinant G-J, Elshout G, van Well G, Francis NA, Winkens B, et al. Trials. BioMed Central; 2016 Nov 17;17(1):547. 

How do general practitioners implement decision-making regarding COPD patients with exacerbations? An international focus group study. Laue J, Melbye H, Halvorsen P, Andreeva E, Godycki-Cwirko M, Wollny A, Francis NA, Spigt M, Kung K, Risør MB. Int J Chron Obstruct Pulmon Dis. 2016;Volume 11:3109–19. 

Parental perceptions and understanding of information provision, management options and factors influencing the decision-making process in the treatment of children with glue ear. Gkiousias V, Butler CC, Shepherd V, Kilgour JM, Waldron C-A, Thomas-Jones E, Francis N. Int J Pediatr Otorhinolaryngol. Elsevier; 2016 Oct;89:6–12. 

Development of a Behavior Change Intervention to Encourage Timely Cancer Symptom Presentation Among People Living in Deprived Communities Using the Behavior Change Wheel.  Smits, S, McCutchan, G, Wood, F, Edwards, A, Lewis, I, Robling, M, Paranjothy, S, Carter, B, Townson, J, Brain, K. Ann. Behav. Med. (2016). doi:10.1007/s12160-016-9849-x

Characterising the nature of primary care patient safety incident reports in the England and Wales National Reporting and Learning System: a mixed-methods agenda-setting study for general practice.
Carson-Stevens A, Hibbert P, Williams H, Evans H, Cooper A, Rees P, Deakin A, Shiels E, Gibson R, Butlin A, Carter B, Luff D, Parry G, Makeham M, McEnhill P, Ward H, Samuriwo R, Avery A, Chuter A, Donaldson L, Mayor S, Panesar S, Sheikh A, Wood FEdwards A.  Health Services and Delivery Research, No. 4.27

Fracture in the Elderly Multidisciplinary Rehabilitation (FEMuR): a phase II randomised feasibility study of a multidisciplinary rehabilitation package following hip fracture.  Williams NH, Roberts JL, Din NU, Totton N, Charles JM, Hawkes CA, Morrison V, Hoare Z, Williams M, Pritchard AW, Alexander S, Lemmey A, Woods RT, Sackley C, Logan P, Edwards RT, and Wilkinson C. BMJ Open 2016;6: e012422. doi:10.1136/ bmjopen-2016-012422

Non-accidental non-fatal poisonings attended by emergency ambulance crews: an observational study of data sources and epidemiology. A John, C Okolie, A Porter, C Moore, G Thomas, R Whitfield, R Oretti, H Snooks. BMJ Open 2016;6:e011049 doi:10.1136/bmjopen-2016-011049.

Emergency Care. Helen Snooks. J.Health Serv Res Policy. July 2016 vol. 21 No. 3 188-194. doi: 10.1177/1355819616644177

Non-accidental non-fatal poisonings attended by emergency ambulance crews: an observational study of data sources and epidemiology. John A, Okolie C, Porter A, Moore C, Thomas G, Whitfield R, Oretti R, Snooks H. BMJ Open. 2016 Aug 18;6(8):e011049. doi: 10.1136/bmjopen-2016-011049.

Patient perspectives and quality of life issues whilst undergoing intermittent or continuous androgen deprivation therapy for prostate cancer: a mixed methods systematic review.  Nafees Din, Andrei Stanciu, Ruth LewisRichard Neal, Eila Watson, Clare Wilkinson. PROSPERO 2016:CRD42016046503

Improving early diagnosis of symptomatic cancer. Hamilton W, Walter FM, Rubin GR, Neal RD. Nature Reviews Clinical Oncology (2016) doi:10.1038/nrclinonc.2016.109 

Barriers to cancer symptom presentation among people from low socioeconomic groups: a qualitative study. McCutchan G, Wood FSmits SEdwards ABrain K. BBMC Public Health (2016) 16:1052 DOI 10.1186/s12889-016-3733-2

Nappy pad urine samples for investigation and treatment of UTI in young children: the ‘DUTY’ prospective diagnostic cohort study. Butler CC, Sterne JA, Lawton M, O’Brien K, Wootton M, Hood K, Hollingworth W, Little P, Delaney BC, van der Voort J, Dudley J, Birnie K, Pickles T, Waldron C, Downing H, Thomsas-Jones E, Lisles C, Rumsby K, Durbaba S, Whiting P, Harman K, Howe R, MacGowan A, Fletcher M, Hay A. British Journal of General Practice. 2016 Jul;66(648):e516-24.

Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study. Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Howe R, MacGowan A, Lawton M, Busby J, Pickles T, Birnie K, O’Brien K, Waldron C, Dudley J, Van der Voort J, Downing H, Thomas-Jones E, Harman K, Lisles C, Rumsby K, Durbaba S, Whiting P, Butler CC. Annals of Family Medicine 2016;14:325-336. doi: 10.1370/afm.1954.

Empiric antibiotic treatment for urinary tract infection in preschool children: susceptibilities of urine sample isolates. Butler CC, O’Brien K, Wootton M, Pickles T, Hood K, Howe R, Waldron CA, Thomas-Jones E, Dudley J, Van Der Voort J, Rumsby K, Little P, Downing H, Harman K, Hay A. Family Practice, 2016, Vol. 33, No. 2, 127–132 doi:10.1093/fampra/cmv104

The Diagnosis of Urinary Tract Infections in Young Children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness. Hay A, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletcher M, Harman K, Hollingworth W, Hood K, Howe R, Lawton M, Lisles C, Little P, MacGowan A, O’Brien K, Pickles T, Rumsby K, Sterne J, Thomas-Jones E, Van Der Voort J, Waldron C, Whiting P, Wootton M, Butler CC, on behalf of the DUTY team. Health Technology Assessment 2016;20(51)

The double edged sword of ovarian cancer information for women at increased risk. Smits, S, Boivin, J, Menon, U, Brain, K. Ecancermedicalscience. 2016; 10: 650. Published online 2016 Jun 30. doi: 10.3332/ecancer.2016.650

Oral steroids for the resolution of otitis media with effusion (OME) in children (OSTRICH): study protocol for a randomised controlled trial. Waldron CA, Thomas-Jones E, Cannings-John R, Hood K, Powell C, Roberts A, Tomkinson A, Fitzsimmons D, Gal M, Harris D, Shepherd V, Butler CC, Francis N. Trials. 2016 Mar 1;17(1):115. doi: 10.1186/s13063-016-1236-1.

Long-term psychosocial outcomes of low-dose CT screening: results of the UK Lung Cancer Screening randomised controlled trial.  Brain K, Lifford KJ, Carter B, Burke O, McRonald F, Devaraj A, Hansell DM, Baldwin D, Duffy SW, Field JK. Thorax. 2016 Nov;71(11):996-1005. doi: 10.1136/thoraxjnl-2016-208283. Epub 2016 Jul 28.

Symptoms, unmet needs, psychological well-being and health status in prostate cancer survivors: implications for redesigning follow-up. Watson E, Shinkins B, Frith E, Neal D, Hamdy F, Walter F, Weller D, Wilkinson C, Faithfull S. Wolstenholme J. Sooriakumaran P, Kastner C, Campbell C, Neal RD, Butcher H, Matthews M, Perera R, Russell S, Rose P. BJU Int. 2016 Jun;117(6B):E10-9. doi: 10.1111/bju.13122.

Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation
Tonkin-Crine S, Anthierens S, Hood K, Yardley L, Cals JW, Francis NA, Coenen S, van der Velden AW, Godycki-Cwirko M, Llor C, Butler CC, Verheij T, Goossens H, Little P; GRACE INTRO/CHAMP consortium. Implement Sci. 2016 May 12;11(1):66. doi: 10.1186/s13012-016-0436-0.

Mixed-methods study to develop a patient complexity assessment instrument for district nurses
Thomas S, Wallace C, Jarvis P, Davis R. Nurse Res. 2016 Mar;23(4):9-13. doi: 10.7748/nr.23.4.9.s3.

Profiling for primary care presentation, investigation and referral for liver cancers – evidence from a national audit.  Hughes DL, Neal RD, Lyratzopoulos G, Rubin GP. European Journal of Gastroenterology and Hepatology. 2016 28(4):428-32.

The symptoms of adult chronic and acute Leukaemia before diagnosis: large primary care case-control studies using electronic records.  Shephard E, Neal RD, Rose PW, Walter FM, Hamilton W. BJGP. 2016; 66(64):e182-8. doi: 10.3399/bjgp16X683989

Occupational health for humanitarian aid workers in an Ebola outbreak. Haggman H, Kenkre JWallace C. Journal of Research in Nursing February 2016 vol. 21 no. 1 22-36 

Costs, effects and implementation of emergency admission risk prediction models in primary care for patients with, or at risk of, chronic conditions: a systematic review protocolKingston MEvans BA, Nelson K, Hutchings H, Russell I, Snooks H. BMJ Open 2016;6:e009653 doi:10.1136/bmjopen-2015-009653 

Development and delivery of a physical activity intervention for people with Huntington Disease: facilitating translation to clinical practice.  Quinn L, Truby R, Gobat N, Dawes H, Tudor Edwards R, Jones C, Townson J, Drew C, Kelson M, Poile V, Rosser A, Busse M. J Neurol Phys Ther 2016; 40: 71–80

Understanding flucloxacillin prescribing trends and treatment non-response in UK primary care: a Clinical Practice Research Datalink (CPRD) studyFrancis NAHood K, Lyons R & Butler CC. J. Antimicrob. Chemother. (2016) doi: 10.1093/jac/dkw084 

Evaluating a computer aid for assessing stomach symptoms (ECASS): study protocol for a randomised controlled trial. Moore HJ, Nixon C, Tariq A, Emery J, Hamilton W, Hoare Z, Kershenbaum A, Neal RD, Ukoumunne OC, Usher-Smith J, Walter FM, Whyte S, Rubin G. Trials, 17:184. 2016. DOI: 10.1186/s13063-016-1307-3

National community pharmacy NHS influenza vaccination service in Wales: a primary care mixed methods study.  Evans AM, Wood F, Carter B. British Journal of General Practice. March 2016; DOI: 10.3399/bjgp16X684349

Prevalence of recommendations made within dental research articles using uncontrolled intervention or observational study designs. Wilson, MK and Chestnutt, I.G. J Evid Based Dent Pract. 2016 Mar;16(1):1-6. doi: 10.1016/j.jebdp.2015.09.003.

Dental consultations in UK general practice and antibiotic prescribing rates: a retrospective cohort study. Cope A, Chestnutt IGWood FFrancis NA. British Journal of General Practice. DOI: 10.3399/bjgp16X684757 Published 30 March 2016 

Symptoms of adult chronic and acute leukaemia before diagnosis: Large primary care case-control studies using electronic records. Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton W. British Journal of General Practice 66(644):e182-e188. March 2016

End-of-life care decisions for haemodialysis patients - "We only tend to have that discussion with them when they start deteriorating". Lazenby S, Edwards A, Samuriwo R, Riley S, Murray M, Carson-Stevens, A. Health Expect. 2016 Mar 10. doi: 10.1111/hex.12454. 

A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study
Francis NA, Ridd MJ, Thomas-Jones E, Shepherd V, Butler CC, Hood K, Huang C, Addison K, Longo M, Marwick C, Wootton M, Howe R, Roberts A, Haq M, Madhok V, Sullivan F. Health Technol Assess. 2016 Mar;20(19):1-84. doi: 10.3310/hta20190.

United Kingdom Lung Cancer RCT Pilot Screening Trial (UKLS): Baseline findings from the screening arm provide evidence for a cost effective exemplar for implementation of lung cancer screening
Field JK, Duffy SW, Baldwin DR, Whynes DK, Devaraj A, Brain K, Eisen T, Gosney J, Green BA, Holemans J, Kavanagh T, Kerr KM, Ledson M, Lifford K, McRonald FE, Nair A, Page R, Parmar MKB, Rassl D, Rintoul RC, Screaton N, Wald NJ, Weller D, Williamson PR, Yadegarfar G, Hansell DM. Thorax 2015;0:1–10.

Neural responses to a modified Stroop paradigm in patients with complex chronic musculoskeletal pain compared to matched controls: an experimental functional magnetic resonance imaging study. Taylor A, Harris A, Varnava A, Phillips R, Hughes O, Wilkes A, Hall J, Wise RG. BMC Psychology 4 (5) , pp. 1-13.

Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care. Olsen JR, Piguet V, Gallacher J, & Francis NA. (2015b). The British Journal of General Practice: the Journal of the Royal College of General Practitioners, 66(642), e53–e58.

International variation in adherence to referral guidelines for suspected cancer: a secondary analysis of survey data.  Nicholson BD, Mant D, Neal RD, Hart N, Hamilton W, Shinkins B, Rubin G, Rose PW. Br J Gen Pract. 2016 Feb;66(643):e106-13. doi: 10.3399/bjgp16X683449.