Title

Development of a point-of-care exhaled-breath analysis instrument.

Principal / Lead investigator

• Dr Bastiaan Hoogendoorn, Cardiff University

Co-investigators / research team

• Dr Jenna Bowen, Cardiff University
• Dr Clive Gregory, Cardiff University
• Dr Colin Powell, Cardiff University

Type of study

Laboratory and case/control study

Summary

This study’s aim is to develop of a point-of-care exhaled-breath analysis instrument that will allow the rapid differentiation of non-bacterial infection, Gram-positive bacterial infection and Gram-negative bacterial infection in children with pneumonia.

Pneumonia is the leading infectious cause of death in children worldwide, accounting for 15% of all deaths of children under five years old. Although the condition can be treated by antibiotics, delayed and ineffective diagnosis means that only one third of children receive the antibiotics they need.

Who is the study sponsor?

Cardiff University

Funder

Bill and Melinda Gates Foundation Grand Challenges Explorations Phase I

Total grant value

£52,133

Start date

01/11/2015

End date

30/04/2017

How could this research potentially benefit public / patients?

An effective point of care test for pneumonia would enable rapid, accurate diagnosis, allowing timely administration of appropriate therapies. This in turn will help to alleviate the significant human cost associated with the condition.

Further information (e.g. related web link)

Towards improving pneumonia diagnosis, 20 November 2015, Cardiff University News:
http://www.cardiff.ac.uk/news/view/164917-towards-improving-pneumonia-diagnosis

Outputs generated (Reports / Publications / Impact)

To follow